An in vivo investigation on the effect of gene- delivered human serine hydrolase KIAA1363 on chemical warfare nerve agent intoxication
نویسنده
چکیده
منابع مشابه
A brain detoxifying enzyme for organophosphorus nerve poisons.
Organophosphorus (OP) insecticides and chemical warfare agents act primarily by inhibiting acetylcholinesterase. There are many secondary targets for OP toxicants as observed for example with the major insecticide chlorpyrifos and its bioactivated metabolite chlorpyrifos oxon (CPO). Therefore, it was surprising that the predominant mouse brain protein labeled in vitro by [(3)H-ethyl]CPO (1 nM) ...
متن کاملTheoretical investigation about the adsorption of the Sarin nerve agent on C20 fullerene and its boron-doped derivative
Sarin is a very toxic organophosphorus chemical warfare agent which has been used in different wars. According to an immediate demand of detection, secure approachs to break down this toxic nerve agent, the study on decomposition of sarin achieve significance. In this work, we have made endeavors of discovering an approach to neutralize this hazardous kind by adsorption of this molecule by C20 ...
متن کاملDual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification.
Serine hydrolase KIAA1363 is an acetyl monoalkylglycerol ether (AcMAGE) hydrolase involved in tumor cell invasiveness. It is also an organophosphate (OP) insecticide-detoxifying enzyme. The key to understanding these dual properties was the use of KIAA1363 +/+ (wildtype) and -/- (gene deficient) mice to define the role of this enzyme in brain and other tissues and its effectiveness in vivo in r...
متن کاملPreparation and Utilization of MnO2 Nanoparticles (NPs) Catalyst for the Decontamination against Chemical Warfare Nerve Agent Simulant (CWNAS)
In this scientific research, MnO2 nanoparticles (NPs) have been successfully prepared by a precipitation method using KMnO4, MnSO4.H2O and H2O2 (30%) as the precursors. As-prepared sample was identified by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM) and Infrared (IR) techniques. The transmission electron microscopy (TEM) showed 7-8 nm rang...
متن کاملSerine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions.
Serine hydrolase KIAA1363 is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated by and hydrolyzing low levels of chlorpyrifos oxon (CPO) (the activated metabolite of a major insecticide). It is also the primary CPO-hydrolyzing enzyme in spinal cord, kidney, heart, lung, testis, and muscle but not liver, a pattern of tissue expression confirme...
متن کامل